Anti-NF-kB p65 (phospho Ser468) Antibody

This rabbit polyclonal antibody from Antibodies.com selectively targets the phosphorylated form of the NF-κB p65 (RelA) transcription factor at Serine 468, a modification associated with negative regulation of NF-κB signaling and modulation of pro-inflammatory gene expression. Phosphorylation at Ser468 is carried out by kinases including GSK-3β and CK2, and has been investigated in the context of cytokine-driven signaling, innate immune activation, and cellular stress responses.

Provided as a 100 µg lyophilised preparation, the antibody is unconjugated and of the IgG isotype, with demonstrated reactivity against mouse and human samples. The reagent supports ELISA workflows and can be incorporated into studies mapping the temporal dynamics of NF-κB pathway activation following stimulation with TNF-α, IL-1β, or LPS.

Investigators working in inflammation, oncology signalling, or immune cell regulation can use this reagent to distinguish between total p65 and the Ser468-phosphorylated pool. Reconstitution guidance is included with the shipment to preserve binding activity.