Anti-NF-kB p65 (phospho Ser276) Antibody

This rabbit polyclonal IgG preparation from Antibodies.com targets the phosphorylated form of the NF-κB p65 (RelA) transcription factor at serine 276, a well-characterised activation-linked post-translational modification. Supplied as a 100 µg lyophilised aliquot, the unconjugated antibody is validated for ELISA and shows documented reactivity against mouse and human samples. Phosphorylation at Ser276 is catalysed by kinases such as PKA and MSK1/2 in response to inflammatory cytokines, DNA damage, and pathogen-associated molecular patterns, and the resulting conformational change promotes p65 association with the coactivator CBP/p300, driving transcription of pro-inflammatory and pro-survival genes. Investigators studying NF-κB pathway activation, innate immunity, chronic inflammation, or oncogenic signalling use this reagent to distinguish activated p65 from the resting pool in cell lysates. The lyophilised format supports stable storage and convenient reconstitution to a working stock, while the polyclonal IgG format provides broader epitope coverage than a monoclonal reagent when probing a single phospho-residue. Intended for research use only, the antibody supports laboratory analysis of signalling events rather than diagnostic or therapeutic applications.