Anti-NF-kB p105 / p50 (phospho Ser337) Antibody

This rabbit polyclonal IgG reagent from Antibodies.com selectively recognizes NF-kB p105 and its processed p50 subunit when phosphorylated at serine 337, a regulatory site that modulates processing and activation of the canonical NF-kB signaling cascade. The unconjugated antibody is supplied as a 100 µg lyophilised preparation and is reactive with both mouse and human samples, supporting translational work in inflammation, immune response, and signaling pathway research.

NF-kB p105 is the cytoplasmic precursor of p50, which dimerizes with RelA/p65 and other Rel-family partners to translocate to the nucleus and drive transcription of cytokines, chemokines, and immune regulatory genes. Phosphorylation at Ser337 is implicated in p105 stability and processing control, making phospho-specific detection valuable for dissecting pathway dynamics under varied stimulation conditions.

Key attributes include host Rabbit, polyclonal clonality, IgG isotype, unconjugated format, reactivity with mouse and human, ELISA application, and a 100 µg lyophilised vial. The unconjugated preparation permits flexible pairing with HRP, fluorophore, or biotin secondary antibodies, while the lyophilised product supports aliquoting for frozen storage and repeated use. Intended for research use only.