Anti-NFκB-p105 / p50 Antibody

Raised in rabbit as a polyclonal reagent, this unconjugated primary antibody from Antibodies.com targets the NFκB-p105 precursor and its processed p50 subunit. NFκB1 functions as a transcription factor central to inflammatory signaling, cytokine regulation, and cellular stress responses, with the p105 precursor constitutively processed into the p50 DNA-binding subunit that forms active dimers with RelA, c-Rel, or RelB family members.

This 100 µl vial is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows, with confirmed reactivity against human and mouse samples. Researchers deploy it to map canonical NFκB activation, monitor IκBα degradation kinetics, or profile nuclear translocation of p50-containing complexes in stimulated cell lines. The unconjugated format allows flexible pairing with custom secondary conjugates, biotinylation, or direct labeling depending on assay requirements. Aliquot upon receipt and store at -20°C to preserve activity across multiple freeze-thaw cycles.