Anti-Netrin-1 Antibody

Netrin-1 is a secreted ~67 kDa laminin-related guidance cue that directs axon outgrowth, cell migration, and angiogenesis during nervous system development, while also acting as a survival signal in adult tissues. This unconjugated rabbit polyclonal reagent from Antibodies.com was raised against the Netrin-1 target and is supplied as a 100 µl vial for use in western blot, immunohistochemistry, and ELISA workflows.

It cross-reacts with Netrin-1 from human, mouse, rat, and monkey samples, giving laboratories a single reagent that covers the most commonly studied mammalian model systems in developmental biology, neuroscience, and oncology research. Because Netrin-1 signaling through DCC and UNC5 family receptors is implicated in tumor cell survival and metastatic dissemination, the antibody is frequently applied to investigate expression patterns in colorectal, breast, and pancreatic cancer tissue sections, as well as in neuronal differentiation and axon guidance studies.

The polyclonal format yields recognition of multiple epitopes on the Netrin-1 protein, supporting detection of both the full-length secreted ligand and processed fragments in cell lysates, tissue homogenates, and conditioned media from in vitro culture systems.