Anti-Nephrocystin-5 Antibody

This polyclonal antibody from Antibodies.com specifically recognizes Nephrocystin-5, a ciliary protein also known as IQCB1 that is encoded by the IQCB1 gene and implicated in Senior-Løken syndrome, a recessive ciliopathy combining nephronophthisis with retinal degeneration. Raised in rabbit, the unconjugated reagent is validated for Western blotting, immunohistochemistry, and ELISA workflows on human samples. Researchers investigating inherited retinal dystrophies, renal tubular pathology, and primary cilia biology use it to localize the target in the connecting cilium of photoreceptors and in primary cilia of renal epithelial cells. Each vial contains 100 µL of antibody, supporting multiple experimental runs, and storage at -20 °C in aliquots helps preserve activity across freeze-thaw cycles. The reactivity profile supports immunostaining of fixed tissue sections where ciliary localization can be visualized at subcellular resolution, while Western blot detection is useful for confirming expression across patient-derived cell lines and tissue lysates associated with NPHP5-linked disease.