Anti-NEIL1 Antibody

NEIL1 (Nei endonuclease VIII-like 1) is a bifunctional DNA glycosylase belonging to the Fpg/Nei family that initiates base excision repair by excising oxidative base lesions, including 8-oxoguanine, thymine glycol, and 5-hydroxyuracil, with a documented preference for damage located within single-stranded or bubble-structured DNA. Associated AP lyase activity then cleaves the abasic site, allowing downstream repair synthesis to complete the pathway. This rabbit polyclonal primary antibody from Antibodies.com is raised against the human NEIL1 protein and supplied unconjugated in a 100 µL volume for Western blot and immunofluorescence applications on human samples. Polyclonal reactivity against the full-length target typically produces consistent signal across denatured and native preparations, and the unconjugated format lets laboratories couple the reagent to fluorophores, horseradish peroxidase, or biotin as each assay requires. Research applications include probing BER pathway activity under oxidative stress, mapping subcellular distribution in cell culture models, and validating expression changes in cancer and neurodegeneration contexts where NEIL1 function is implicated. For handling, refrigerate the antibody upon arrival, aliquot to limit freeze-thaw cycles, and protect from light during extended storage.