Anti-NEDD8 Antibody

Generated in rabbit against the ubiquitin-like modifier NEDD8, this polyclonal reagent from Antibodies.com detects the 9 kDa neddylation substrate across human, mouse, and rat samples. NEDD8 is best known for its covalent conjugation to cullin scaffold proteins, which activates cullin-RING E3 ubiquitin ligases and downstream pathways including cell cycle control, NF-κB signaling, and the DNA damage response. Researchers apply this unconjugated antibody in western blot, immunohistochemistry, and immunofluorescence workflows that probe neddylation dynamics, deneddylation by NEDP1, and the interplay between NEDD8 and ubiquitin pathways. The 100 µL aliquot ships in a vial format that fits both pilot experiments and ongoing studies, and the polyclonal formulation increases the likelihood of recognizing multiple epitopes on the mature NEDD8 protein as well as its precursor form.