Anti-Nectin 2 Antibody

The polyclonal antibody offered by Antibodies.com targets Nectin 2, a calcium-independent immunoglobulin-like cell adhesion molecule of the nectin family that localises to adherens junctions and serves as an entry receptor for herpes simplex virus and pseudorabies virus. Raised in Rabbit and supplied as an unconjugated reagent in a 100 µl vial, the antibody is validated for Western blot and ELISA applications against human samples. Nectin 2, also known as PVRL2 or CD112, interacts intracellularly with afadin to couple adhesion to the actin cytoskeleton and is implicated in immune synapse organisation, spermatogenesis, and the regulation of cadherin-based contacts, making it a useful marker in studies of junctional biology, viral entry mechanisms, and tumour cell adhesion. Researchers examining epithelial polarity, virus–host interactions, and cell–cell communication can use this polyclonal reagent to detect endogenous human Nectin 2 in lysates and protein preparations.