Anti-NDUFS4 Antibody

Mitochondrial Complex I research relies on accurate subunit detection, and this rabbit polyclonal reagent targets NDUFS4, the NADH:ubiquinone oxidoreductase core subunit S4 located within the peripheral arm of respiratory chain Complex I on the inner mitochondrial membrane. Raised in rabbit and supplied unconjugated in a 100 µl vial, the antibody is validated for western blot and immunohistochemistry workflows against human and mouse samples.

Investigators studying Leigh syndrome, Parkinson's disease models, and other mitochondrial disorders frequently use NDUFS4 expression as a marker of Complex I assembly and stability. The protein is also tracked within OXPHOS subunit panels when assessing oxidative phosphorylation capacity in highly oxidative tissues such as brain, cardiac muscle, and skeletal muscle. Storage at -20°C in working aliquots helps preserve reactivity across multiple freeze-thaw cycles, and the polyclonal format provides broader epitope coverage than a monoclonal alternative.

This reagent is part of the primary antibody portfolio offered by Antibodies.com for researchers investigating mitochondrial respiratory chain biology.