Anti-NDRG3 Antibody

This rabbit polyclonal antibody targets NDRG3 (N-Myc Downstream Regulated Gene 3), a cytoplasmic protein of the NDRG family that participates in stress responses, hypoxia adaptation, and cellular differentiation. Produced by Antibodies.com, the reagent is supplied as 100 µL of unconjugated polyclonal antiserum raised in rabbit, and it is validated for western blot (WB) and immunohistochemistry (IHC) workflows.

NDRG3 is regulated through proline hydroxylation and proteasomal turnover under low-oxygen conditions, and the antibody is commonly used to characterize this pathway in research on tumor hypoxia, neuronal stress, and metabolic regulation. The reagent recognizes the human, mouse, and rat orthologues, enabling comparative studies across cell and tissue models derived from these species.

For western blot, the reagent produces a band near the expected molecular weight for NDRG3 in whole-cell lysates; for IHC, it is applied to formalin-fixed paraffin-embedded sections to localize expression in tissues such as brain, testis, and developing epithelia. Shipped refrigerated; aliquot upon arrival to limit freeze-thaw cycles and protect from light to preserve activity over its shelf life.