Anti-NCSTN Antibody

Targeting nicastrin, the substrate-recruiting subunit of the gamma-secretase intramembrane protease complex, this rabbit polyclonal reagent from Antibodies.com enables detection of NCSTN in western blot and immunohistochemistry workflows using human, mouse, and rat samples. Supplied as 100 µl of unconjugated antisera, the antibody supports investigations of amyloid precursor protein processing, Notch receptor signaling, and the loss-of-function variants in NCSTN that have been linked to familial acne inversa. Researchers commonly apply the reagent at optimized dilutions for immunoblotting of membrane-enriched lysates or chromogenic staining of fixed tissue sections. For handling, store the vial at -20 degrees C in small aliquots and avoid repeated freeze-thaw cycles to preserve antigen-binding activity across extended studies.