Anti-NCSTN Antibody

Nicastrin (NCSTN) serves as the substrate-recognition subunit of the gamma-secretase complex, and this rabbit polyclonal primary antibody from Antibodies.com enables detection of the protein across human, mouse, and rat samples. Validated for Western blot and immunohistochemistry workflows, the reagent is supplied unconjugated in a 100 µl volume at 1 mg/ml, formulated in PBS with 0.1% sodium azide and 50% glycerol for storage stability.

Nicastrin is a single-pass transmembrane glycoprotein essential for gamma-secretase assembly and activity, with established roles in amyloid precursor protein (APP) processing and Notch receptor signaling. The polyclonal format recognizes multiple epitopes on the target, supporting detection of both full-length and processed Nicastrin species in lysate preparations and tissue sections. Researchers studying familial hidradenitis suppurativa, Alzheimer's disease models, and developmental Notch signaling commonly use anti-Nicastrin reagents to characterize component expression in neural, epithelial, and inflammatory tissues.