Anti-NCS1 Antibody

This polyclonal antibody from Antibodies.com targets NCS1 (Neuronal Calcium Sensor 1), an EF-hand calcium-binding protein expressed across neuronal and neuroendocrine tissues. Raised in rabbit, the unconjugated reagent is supplied as 100 µl aliquots and is validated for Western blot and immunofluorescence workflows on human, mouse, and rat samples.

NCS1 participates in intracellular calcium signaling, modulating neurotransmitter release, synaptic vesicle trafficking, and neurite outgrowth. Researchers studying synaptic plasticity, learning, and memory frequently employ this reagent to map expression patterns in hippocampal and cortical neurons. The antibody has also been applied in investigations of psychiatric disorders such as bipolar disorder and schizophrenia, where altered NCS1 levels have been documented in patient-derived lymphocytes and postmortem brain tissue.

Beyond neuroscience, NCS1 expression has been characterized in several cancer cell lines, including breast carcinoma models, supporting its use in tumor biology research. The polyclonal nature of the reagent allows recognition of multiple epitopes on the ~22 kDa target, which can be helpful when working with splice variants or partially denatured samples. For immunofluorescence, the antibody performs well on fixed cultured neurons and brain sections, producing cytoplasmic and membrane-associated staining consistent with known NCS1 localization.