Anti-NCAN Antibody

This unconjugated rabbit polyclonal IgG, distributed by Antibodies.com, targets Neurocan (NCAN), a chondroitin sulfate proteoglycan concentrated in the central nervous system extracellular matrix where it influences axon guidance, neural progenitor behavior, and post-injury plasticity. Validated for Western blot and immunohistochemistry workflows, the reagent detects the endogenous proteoglycan in human, mouse, and rat tissue sections and lysates. Packaged as 200 µL of affinity-purified antiserum in a single-use vial, the reagent suits labeling of perineuronal nets and probing developmental versus lesioned brain samples, as well as studies of psychiatric-disorder-associated risk loci. Storage: refrigerate at 4°C for active use; aliquot to limit freeze-thaw cycles and protect from light during extended storage. Researchers commonly deploy this reagent to map NCAN expression across cortical layers, characterize knockout phenotypes, or compare matrix remodeling in stroke and injury models.