Anti-NBR1 Antibody

A multidomain scaffolding protein, NBR1 (Neighbor of BRCA1 Gene 1) partners with p62/SQSTM1 through shared PB1 domains to capture ubiquitinated substrates and tether them to LC3-positive autophagosomes via its LIR motif, making it a central marker for selective autophagy pathways including aggrephagy, mitophagy, pexophagy, and xenophagy. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is affinity purified and validated for western blot detection of endogenous human, mouse, and rat NBR1 in cell and tissue lysate samples. Researchers use it to track autophagic flux and cargo turnover in neurodegeneration, cancer, and infection models, frequently probing NBR1 alongside p62 to compare condensate formation against lysosomal degradation. Each 100 µL liquid vial ships unconjugated, leaving laboratories free to pair the primary with any HRP- or fluorophore-labeled secondary of their choice. For storage, keep the vial frozen at -20°C in small working aliquots and avoid repeated freeze-thaw cycles to preserve binding activity across multiple immunoblotting experiments. For research use only.