Anti-NAT8 Antibody

Raised in rabbit against N-acetyltransferase 8, this unconjugated polyclonal reagent from Antibodies.com recognises an enzyme best known for catalysing N-terminal protein acetylation on nascent ribosomal polypeptides. The 100 µl volume is supplied ready for Western blot (WB) and immunohistochemistry (IHC) workflows, with confirmed reactivity against both human and mouse NAT8, supporting side-by-side work on patient-derived specimens and mouse disease models.

NAT8, also annotated in earlier literature as FASN2 or GNA1, has drawn increasing research attention because altered expression is associated with renal cell carcinoma, hepatocellular carcinoma, and other solid tumours, where disrupted N-terminal acetylation perturbs proliferation, apoptosis, and turnover of key metabolic enzymes. Typical deployments include chromogenic IHC on formalin-fixed, paraffin-embedded tissue arrays to score stromal versus epithelial NAT8 distribution, and Western blot on whole-cell lysates from CRISPR-Cas9 knockout lines to verify loss of the target band. The unconjugated format lets users pair the reagent with their preferred HRP-, biotin-, or fluorophore-tagged secondary antibody and titrate independently for chemiluminescent film or immunofluorescence detection.

Handle the vial with standard cold-chain practice: aliquot on first thaw to limit freeze-thaw cycles, keep refrigerated for short-term bench use, and reserve a frozen stock for long-term stability. For research use only.