Anti-MYSM1 Antibody

From Antibodies.com, this rabbit polyclonal reagent targets MYSM1, a chromatin-associated metalloprotease that selectively deubiquitinates histone H2A and regulates hematopoietic stem cell function, B cell lineage commitment, and stress-induced immune responses. Supplied at 200 µl per vial as an unconjugated IgG preparation, the antibody is validated for western blot and flow cytometry workflows with both human and mouse samples.

MYSM1 expression is enriched in hematopoietic and germline tissues, and the reagent is widely used in studies of chromatin-mediated transcriptional regulation, DNA damage response pathways, and tumor biology. Recent investigations have linked MYSM1 activity to colorectal cancer, melanoma, and acute myeloid leukemia, where reduced deubiquitinase function is associated with altered proliferation and genomic instability. Published work has also connected MYSM1 loss with defects in lymphoid development and impaired clearance of damaged cells, supporting its use in immunology and stem cell research.

Provided unconjugated, the antibody pairs with the researcher's preferred secondary detection chemistry, including HRP for chromogenic western blots or fluorophore conjugates for multicolor flow cytometry panels. The polyclonal IgG host response supports recognition of multiple epitopes on MYSM1, providing an advantage when probing native protein complexes or detecting low-abundance targets across cultured cell lysates, tissue homogenates, and primary samples. As a research use only reagent intended for in vitro laboratory applications, it is well suited for chromatin immunoprecipitation follow-up, signaling studies, and routine verification of MYSM1 expression in established cell line panels.