Anti-MYOT Antibody

This polyclonal antibody from Antibodies.com targets MYOT (myotilin), a sarcomeric Z-disc protein that organizes thin filaments and tethers alpha-actinin in striated muscle. Raised in rabbit and supplied unconjugated at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the reagent is validated for Western blot and immunohistochemistry on human tissue samples.

Investigators use this reagent to study myofibrillar myopathies and limb-girdle muscular dystrophy type 1A, both linked to MYOT mutations that compromise Z-disc integrity in skeletal and cardiac muscle. The 100 µl format supports multiple staining and blotting experiments, and aliquoting is advised to limit freeze-thaw cycles. Store at -20 °C in working aliquots, where the glycerol component serves as a cryoprotectant to preserve antibody activity across repeated use.