Anti-Myosin VIIa Antibody

Raised in rabbit, this unconjugated polyclonal reagent targets an unconventional actin-based motor protein required for the organization and function of sensory hair cell stereocilia in the inner ear, as well as for retinal pigment epithelium homeostasis. Antibodies.com supplies the antibody at 1 mg/ml in phosphate buffered saline (PBS) with 0.05% sodium azide at approximately pH 7.2, packaged as 100 µl per vial. Validated for western blot on human samples, the reagent recognizes the ~254 kDa MYO7A gene product, with mutations in this gene underlying Usher syndrome type 1B and dominant forms of non-syndromic hearing loss such as DFNA11. Storage at 4 °C is appropriate for short-term use; for longer-term storage, aliquot and freeze to preserve activity. The host species is rabbit, the clonality is polyclonal, and the conjugate is unconjugated, allowing flexibility in downstream detection chemistry, including HRP, biotin, or fluorophore labeling by the end user.