Anti-MYH2 Antibody

This rabbit polyclonal antibody targets MYH2, the gene encoding myosin heavy chain IIa, a contractile protein expressed predominantly in fast-twitch type IIa skeletal muscle fibers. Antibodies.com supplies this reagent as an unconjugated IgG preparation validated for Western blot analysis of human samples. Researchers in muscle physiology, exercise biology, and neuromuscular disease use anti-MYH2 to resolve type IIa fiber content and to study sarcomeric assembly in skeletal muscle lysates. The antibody is provided in a 200 µL liquid aliquot and reacts with human MYH2 antigen. On standard SDS-PAGE gels, MYH2 migrates near 220-225 kDa, consistent with the intact myosin heavy chain protein. Polyclonal rabbit antibodies give broad epitope coverage for detecting the full-length target in denatured lysates prepared from skeletal muscle biopsies or cultured myotubes. The reagent supports research use only applications including fiber-type composition studies, investigation of muscular dystrophies, and characterization of MYH2-related myopathies such as distal arthrogryposis type 1 linked to MYH2 mutations.