Anti-MyD88 Antibody

MyD88 (Myeloid Differentiation Primary Response 88) is a critical cytoplasmic adaptor protein that mediates signaling downstream of Toll-like receptors and the IL-1 receptor superfamily, coupling innate immune receptor activation to NF-κB and MAPK pathways. This anti-MyD88 reagent from Antibodies.com is a rabbit polyclonal antibody raised against the target and validated for western blot, immunohistochemistry, and immunofluorescence workflows on human, mouse, and rat specimens.

Supplied unconjugated in a 100 µl vial, the antibody is intended for detection of endogenous MyD88 in cell lysates, fixed tissue sections, and cultured mammalian cells. Investigators studying TLR signaling, sepsis, autoimmunity, autoinflammatory disease, and mucosal immunity rely on polyclonal anti-MyD88 reagents to compare basal and induced expression across experimental and control cohorts. The unconjugated format allows pairing with a user-selected secondary detection system, including HRP conjugates, Alexa Fluor dyes, or biotin-streptavidin reagents.

Long-term storage at -20 °C in single-use aliquots is recommended to preserve activity and limit freeze-thaw exposure. On reducing western blots, the target is typically resolved near 33 kDa, consistent with the molecular weight of full-length MyD88, although apparent mobility can shift with post-translational modification and gel conditions.