Anti-MUTYH Antibody

Antibodies.com offers this rabbit polyclonal reagent targeting MUTYH (MutY Homolog), a DNA glycosylase that initiates base excision repair by excising adenines misincorporated opposite 8-oxoguanine, one of the most prevalent forms of oxidative DNA damage. Because unrepaired 8-oxoG:A mispairs drive G:C to T:A transversions during replication, the enzyme is central to studies of mutagenesis, mitochondrial genome maintenance, and the molecular pathology of MUTYH-associated polyposis (MAP), the autosomal recessive colorectal cancer predisposition syndrome caused by biallelic MUTYH loss-of-function.

Supplied as 100 µl of unconjugated antiserum in a vial, the antibody has been validated for western blot (WB) and immunofluorescence (IF) workflows and cross-reacts with human, mouse, and rat samples, supporting comparative work across cultured cell lines, primary tissue, and animal models of oxidative stress or colorectal tumorigenesis. The polyclonal format increases the likelihood of recognising multiple epitopes across full-length MUTYH and its processed forms, an advantage when probing DNA damage response signalling, subcellular localisation, and genotype–phenotype correlations in patient-derived material.