Anti-MUC1 Antibody

This polyclonal reagent targets Mucin 1 (MUC1), a heavily glycosylated transmembrane glycoprotein normally expressed on the apical surface of glandular and ductal epithelia. Aberrant overexpression and hypoglycosylation of MUC1 are hallmarks of multiple carcinomas, including breast, ovarian, lung, colon, and pancreatic tumors, and the extracellular portion of the molecule is shed into circulation where it serves as the basis for clinical tumor markers such as CA 15-3 and CA 27.29.

Raised in rabbit and supplied as an unconjugated preparation in a 100 µl vial, this antibody is validated for Western blotting (WB) and immunohistochemistry (IHC) on human samples. Polyclonal reactivity to multiple epitopes across the MUC1 protein makes it a flexible choice for tracking full-length and cleaved forms in cell lysates and for visualizing MUC1 localization in formalin-fixed tissue sections.

Researchers commonly apply Anti-MUC1 Antibody from Antibodies.com to investigate epithelial differentiation, characterize tumor-associated glycoforms, study receptor signaling through the MUC1 cytoplasmic tail, and validate MUC1 expression in patient-derived xenografts. Short-term refrigerated storage in the supplied vial preserves reagent activity for routine use; for longer projects, aliquot and freeze at -20 °C to limit freeze-thaw cycles.