Anti-mTOR (phospho S2448) Antibody

This phospho-specific polyclonal antibody recognizes mTOR only when serine 2448 is phosphorylated, a modification that marks active engagement of the PI3K/AKT/mTORC1 signaling axis in growth factor and nutrient sensing. Raised in rabbit and supplied in a vial as an unconjugated IgG preparation, this reagent from Antibodies.com is validated for Western blot, immunohistochemistry, and immunofluorescence workflows on human samples.

Phosphorylation at S2448 is catalyzed by AKT and is widely used as a downstream readout of pathway activity in tumor biology, metabolic disease models, and cell signaling studies. Investigators apply this antibody to biopsy sections, cultured cell lines, and primary cells to monitor responses to rapamycin, insulin, amino acid availability, and cellular stress. The 100 µl volume supports dozens of immunoblots or multiple staining experiments, and aliquoting upon arrival preserves the phospho-epitope across repeated freeze-thaw cycles for research use only.