Anti-MTMR14 Antibody

Polyclonal antibodies from Antibodies.com targeting the human MTMR14 myotubularin-related phosphatase support reliable detection across multiple experimental platforms. This unconjugated rabbit reagent is supplied as 100 µl of a 1 mg/ml stock in PBS buffer containing 0.1% sodium azide and 50% glycerol, ready for direct labeling or use in standard immunodetection workflows. Validated applications include Western blot and immunohistochemistry, with demonstrated reactivity against human, mouse, and rat tissue samples.

MTMR14 is a phosphoinositide 3-phosphatase that regulates endosomal trafficking and autophagy in skeletal and cardiac muscle. Researchers investigating centronuclear myopathy, neuromuscular junction biology, or PtdIns3P-dependent signaling pathways commonly cite this reagent for studies of muscle differentiation and metabolic stress responses. The polyclonal format provides broader epitope coverage than monoclonal alternatives, which can be advantageous when target abundance is low or when detecting multiple isoforms.

Storage recommendations include -20 °C for long-term stability, with aliquots recommended to minimize freeze-thaw cycles of the glycerol-supplemented buffer. The unconjugated format allows flexibility with secondary reporter choices, including HRP, biotin, or fluorophore conjugates, supporting both chromogen and fluorescence-based detection in fixed tissue sections and on immunoblotting membranes.