Anti-MTAP Antibody

This polyclonal reagent from Antibodies.com targets methylthioadenosine phosphorylase (MTAP), a key enzyme in the methionine salvage pathway that is frequently co-deleted with CDKN2A in malignant mesothelioma, pancreatic adenocarcinoma, and high-grade gliomas. Raised in rabbit against the human protein, the unconjugated antibody is supplied as a 100 µl vial and is validated for Western blot, immunohistochemistry, and immunofluorescence workflows on human samples.

Researchers commonly use this reagent to assess MTAP status as a surrogate marker for 9p21 homozygous deletion in tumor specimens, complementing FISH or sequencing strategies when validating cell line panels or characterizing formalin-fixed paraffin-embedded tissue microarrays. Loss of MTAP expression is increasingly recognized as a stratification tool in studies of synthetic lethality involving MAT2A and PRMT5 inhibitors, making reliable detection of the endogenous protein essential for both basic research and translational oncology programs.