Anti-MSK1 (phospho-T581) Antibody

This rabbit polyclonal antibody specifically detects the phosphorylated form of MSK1 (Mitogen- and Stress-activated protein Kinase 1) at threonine 581, a regulatory residue within the C-terminal kinase domain whose modification is associated with cellular responses to mitogenic and inflammatory stimuli. The reagent is supplied by Antibodies.com as an unconjugated IgG preparation at 1 mg/ml in phosphate buffered saline (PBS) containing 15 mM sodium azide, at approximately pH 7.2.

Validated for Western blot (WB) workflows, the antibody recognizes MSK1 from human, mouse, and rat samples, supporting comparative signaling studies across commonly used mammalian model systems. Polyclonal reactivity provides broader epitope coverage than monoclonal alternatives, which is advantageous for tracking phospho-T581 dynamics within MAPK and p38 cascades and for probing downstream events including chromatin remodeling and immediate-early gene expression.

The product ships in a 100 µl vial format. Sodium azide acts as a preservative; aliquots can be exchanged into azide-free buffer if downstream applications require it. For handling, refrigerate for short-term use or freeze for longer storage, and protect from light to preserve activity across repeated experiments.