Anti-MSH6 Antibody - Identical to Abcam (ab180832)

This rabbit polyclonal IgG antibody targets the MSH6 DNA mismatch repair protein and is supplied as an unconjugated 50 µl preparation for Western blot and immunofluorescence workflows. MSH6 (MutS Homolog 6) partners with MSH2 to form the MutSα heterodimer, which scans the genome for base-base mismatches and small insertion-deletion loops introduced during DNA replication. Loss-of-function mutations or epigenetic silencing of MSH6 are a defining feature of Lynch syndrome (hereditary nonpolyposis colorectal cancer) and are routinely screened in microsatellite-unstable colorectal, endometrial, and gastric tumors, making this antigen a widely used marker in MMR-deficient cancer research.

The reagent cross-reacts with both human and mouse MSH6, supporting parallel studies in patient-derived tumor material and in mouse models of carcinogenesis. Researchers commonly apply it to confirm MSH6 expression by Western blot, where the target migrates near 160 kDa, and to visualize nuclear MSH6 localization by immunofluorescence in fixed cells. As an unconjugated polyclonal, it is compatible with a broad selection of secondary antibody conjugates and standard chemiluminescent or fluorescent detection protocols.

From Antibodies.com, this reagent serves laboratories investigating DNA repair pathways, hereditary cancer predisposition, and tumor suppressor biology as a practical alternative to the comparable Abcam reference antibody.