Anti-MSH6 Antibody - Identical to Abcam (ab180832)

A rabbit-derived primary reagent for studying DNA mismatch repair, this unconjugated polyclonal IgG detects MSH6 in human and mouse samples. Supplied as 200 µl, it is validated for Western blot (WB) and immunofluorescence (IF), supporting immunoblot analysis of full-length protein in cell lysates and localization studies in fixed cells.

MSH6 (MutS homolog 6) works with MSH2 to recognize base-base mismatches and small insertion/deletion loops arising during DNA replication. The antibody targets epitopes in the N-terminal region of the protein, making it useful for experiments examining mismatch-repair pathway activity, protein expression, and subcellular distribution. In cancer research, MSH6 loss-of-function changes are associated with Lynch syndrome (HNPCC) and microsatellite instability in sporadic colorectal, endometrial, and gastric tumors; staining or immunoblotting can help characterize these alterations alongside appropriate controls. The unconjugated format from Antibodies.com allows selection of compatible secondary antibodies and detection chemistries for the experimental workflow.