Anti-MSH6 Antibody - Identical to Abcam (ab180832)

The MSH6 protein (MutS Homolog 6) is a critical component of the DNA mismatch repair (MMR) machinery, recognizing base-base mismatches and small insertion-deletion loops that arise during DNA replication. Loss of MSH6 function is associated with microsatellite instability (MSI) and is a hallmark of Lynch syndrome and several sporadic cancers, including colorectal and endometrial tumors. This Antibodies.com reagent is a rabbit polyclonal IgG antibody raised against human MSH6 and validated for Western Blot (WB) and Immunofluorescence (IF) workflows. It cross-reacts with Mouse orthologs and is supplied as an unconjugated antiserum in a 100 µl vial, allowing flexible pairing with secondary antibodies or custom fluorophore and enzyme conjugates. Researchers use it to probe MMR pathway integrity in tumor cell lines and patient-derived tissue, characterize MSI status, and stratify samples for studies of chemotherapy response and immune checkpoint inhibitor sensitivity. Storage at -20°C in small aliquots is recommended to limit freeze-thaw cycles and preserve antibody activity over extended use.