Anti-MSH6 Antibody

This polyclonal antibody from Antibodies.com targets MSH6 (MutS Homolog 6), a key component of the DNA mismatch repair (MMR) system that recognizes and corrects base-pair mismatches and small insertion/deletion loops generated during replication. Raised in rabbit and supplied as an unconjugated reagent in a 100 µl vial, it is validated for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) applications across human, mouse, and rat samples. Researchers use this reagent to assess MSH6 protein expression in tumor specimens and cell lines, particularly in studies of Lynch syndrome (hereditary nonpolyposis colorectal cancer) and sporadic cancers of the colon, endometrium, ovary, and stomach where MSH6 loss is implicated in microsatellite instability. The antibody supports investigations into MMR-deficient phenotypes and helps characterize the MutSα heterodimer alongside MSH2.