Anti-MSH3 Antibody

This Rabbit polyclonal antibody from Antibodies.com targets MSH3 (MutS Homolog 3), a DNA mismatch repair protein that plays a critical role in correcting base-pair mismatches and small insertion-deletion loops generated during DNA replication. MSH3 forms heterodimers with MSH2 (MutSα complex) and contributes to genome stability, with loss-of-function variants implicated in microsatellite instability, Lynch syndrome biology, and tumor progression.

The reagent is supplied as 50 µl of unconjugated antisera, raised in Rabbit, and is validated for Western blot (WB) and immunohistochemistry (IHC) workflows on human samples. Its polyclonal profile increases the likelihood of recognizing multiple epitopes across the MSH3 protein, which is particularly useful when probing truncated isoforms or low-expression tumor specimens where single-clone reagents may fail. Researchers studying mismatch repair deficiency, hereditary cancer cohorts, or chemotherapeutic response pathways commonly deploy MSH3 detection alongside MSH2 and MSH6 within a broader antibody panel. Reactivity has been confirmed against human targets.

Aliquot upon receipt and store refrigerated at 4 °C, avoiding repeated freeze-thaw cycles to preserve antibody titer over long-term use. The reagent is intended for research use only and has not been validated for diagnostic or therapeutic applications.