Anti-MSH3 Antibody

MSH3 (MutS Homolog 3) is a DNA mismatch repair protein that pairs with MSH2 to form the MutSβ heterodimer, which scans replicating DNA for insertion-deletion loops and small mispairs. Loss or dysregulation of MSH3 contributes to microsatellite instability, a phenotype frequently studied in colorectal, endometrial, and other Lynch-spectrum tumors where mismatch repair deficiency guides clinical decision-making. Antibodies.com offers this unconjugated rabbit polyclonal reagent raised against the human MSH3 target and validated for Western blot and immunohistochemistry workflows on human samples. Polyclonal antibodies bind multiple epitopes across the antigen, an advantage when probing denatured lysates or fixed tissue sections where single-epitope monoclonal coverage may be limiting. The 100 µl liquid format is supplied ready to dilute into standard antibody diluent, and the reagent should be stored frozen at -20°C in working aliquots to limit freeze-thaw degradation. Researchers studying MMR-deficient tumors, microsatellite instability status, or the consequences of MSH3 loss use this reagent alongside MMR panel markers such as MSH2, MSH6, and MLH1 in matched cohort analyses.