Anti-MSH3 Antibody

Affinity-purified rabbit polyclonal IgG from Antibodies.com, supplied as a 50 µl liquid aliquot and validated for Western blot and immunohistochemistry workflows on human, mouse, and rat samples. The unconjugated primary antibody targets MSH3, the DNA mismatch repair protein that pairs with MSH2 to form the MutSβ heterodimer responsible for recognizing insertion-deletion loops during post-replicative repair.

The polyclonal reagent binds multiple epitopes on the MSH3 protein, supporting sensitive detection in studies of microsatellite instability, Lynch syndrome biology, and tumor progression pathways. The unconjugated format allows laboratories to choose their own chromogenic, fluorescent, or enzymatic secondary detection strategy without steric interference from a conjugated label.

Investigators working in colorectal cancer biology, DNA repair pathway characterization, or comparative animal model research can apply this antibody to fixed tissue sections and lysed cell preparations, including xenograft and knockout tissue samples. Shipped at 4°C and intended for storage at -20°C; aliquot upon delivery to limit freeze-thaw cycles and preserve reagent activity across multiple experimental runs. For research use only.