Anti-MSH3 Antibody

This polyclonal reagent from Antibodies.com targets MSH3 (MutS Homolog 3), a DNA mismatch repair protein that pairs with MSH2 to form the MutSβ complex. Raised in rabbit and supplied as an unconjugated IgG in a 100 µl volume, it is validated for Western blot and immunohistochemistry workflows. The antibody cross-reacts with human, mouse, and rat MSH3, supporting translational studies across species in xenograft and rodent tissue models. MSH3 biology is central to research on microsatellite instability, trinucleotide repeat expansion disorders such as Huntington's disease and fragile X syndrome, and tumor suppressor pathways. Researchers use this reagent to probe MutSβ-dependent repair, examine repeat expansions in patient-derived samples, and characterize mismatch repair-deficient cell lines. The unconjugated format allows flexible pairing with HRP-, biotin-, or fluorophore-conjugated secondary antibodies for chromogenic or immunofluorescence detection.