Anti-MSH2 Antibody

MSH2 (MutS Homolog 2) plays a central role in the DNA mismatch repair (MMR) pathway, partnering with MSH6 to form the MutSα heterodimer and with MSH3 to form MutSβ. This rabbit polyclonal antibody from Antibodies.com recognizes human and mouse MSH2 and is supplied at 100 µl in an unconjugated format suitable for western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows.

Defects in MSH2 are strongly linked to Lynch syndrome (hereditary nonpolyposis colorectal cancer) and drive microsatellite instability (MSI) in multiple tumor types, including colorectal, endometrial, ovarian, and gastric cancers. Researchers apply this reagent to assess MMR protein expression in tumor biopsies, characterize MMR-deficient cell lines, and investigate the molecular basis of genome instability in cancer biology and DNA repair studies.

The unconjugated format offers flexibility for pairing with custom secondary antibodies, fluorophore conjugates, or enzyme-based detection systems. Anti-MSH2 antibodies are commonly used alongside markers such as MLH1, MSH6, PMS2, and MSH3 to build complete MMR expression profiles in tissue microarrays and clinical pathology workflows, supporting both basic research and translational investigations into hereditary cancer syndromes.