Anti-MSH2 Antibody

MSH2 (MutS Homolog 2) is a central component of the DNA mismatch repair (MMR) machinery, pairing with MSH6 to form the MutSα complex that recognizes base-base mismatches and with MSH3 to form MutSβ for small insertion/deletion loops. This unconjugated rabbit polyclonal antibody from Antibodies.com targets MSH2 and is supplied at 1 mg/ml in PBS with 0.1% Sodium Azide and 50% Glycerol, packaged as a 100 µl vial. Cross-reactivity is reported for Human, Mouse, and Rat samples, supporting translational work in mismatch repair biology and comparative oncology studies.

The reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows, making it suitable for probing MMR status in tumor sections, cell lysates, and fixed tissue preparations. Polyclonal recognition broadens epitope coverage, helpful when assessing MSH2 expression in Lynch syndrome-associated tumors and microsatellite instability models. Store frozen at -20°C in the supplied glycerol buffer, protect from light, and aliquot upon receipt to limit freeze-thaw cycles for long-term research use.