Anti-MSH2 Antibody

MSH2 (MutS Homolog 2) is a key component of the DNA mismatch repair (MMR) system, and loss-of-function mutations in MSH2 are strongly linked to Lynch syndrome (hereditary nonpolyposis colorectal cancer) and to a wide range of sporadic tumors. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against human MSH2 and cross-reacts with mouse and rat samples, supporting comparative studies in DNA repair and oncology research.

Supplied as a 200 µl aliquot of IgG, the reagent is validated for western blot (WB) and immunoprecipitation (IP) workflows. Researchers use it to probe MSH2 expression in cell lysates and tissue extracts, to assess MMR proficiency, and to investigate microsatellite instability in colorectal, endometrial, and other MMR-deficient tumor models. The unconjugated IgG format allows pairing with secondary conjugates of choice, including HRP, biotin, or fluorophore systems tailored to a given detection platform.

For best results, store the antibody at -20 °C in working aliquots to minimize freeze-thaw cycles, and avoid prolonged exposure to room temperature. Brief centrifugation prior to use helps recover any aggregated material.