Anti-MSH2 Antibody

Raised in rabbit against the human MSH2 protein, this unconjugated polyclonal IgG antibody targets MutS Homolog 2, a central component of the DNA mismatch repair (MMR) machinery that recognizes base-base mismatches and small insertion-deletion loops generated during replication. Loss-of-function mutations in MSH2 are strongly linked to Lynch syndrome (hereditary nonpolyposis colorectal cancer) and a range of sporadic tumors, making reliable detection of the protein essential for MMR-deficient phenotype studies and clinical research workflows.

From Antibodies.com, the reagent is supplied as 100 µl of ready-to-use antiserum, packaged in a single vial and validated for Western Blot and Immunoprecipitation (IP) applications across Human, Mouse, and Rat samples. The polyclonal format provides multi-epitope recognition of MSH2, an advantage when probing truncating variants or assessing expression levels in cell lysates and tumor-derived extracts. The unconjugated presentation allows direct coupling to HRP, biotin, or fluorophore labels to suit individual assay designs.