Anti-MRP-L11 Antibody

Mitochondrial ribosomal protein L11 (MRP-L11) is a structural constituent of the large 39S subunit of the human mitoribosome, where it contributes to translation of mitochondrially encoded oxidative phosphorylation subunits. Beyond its structural role, MRP-L11 has emerged as a key regulator in ribosomal stress signaling: free MRP-L11 binds MDM2 and stabilizes p53, linking mitochondrial translation status to nucleolar and tumor-suppressive pathways studied in cancer biology and mitochondrial disease research.

This unconjugated rabbit polyclonal reagent from Antibodies.com is validated for western blot, immunohistochemistry, immunofluorescence, and ELISA workflows, and it cross-reacts with human and monkey (primate) samples. Provided as 100 µl of polyclonal antiserum suitable for multiple rounds of probing, the antibody offers a flexible primary reagent for laboratories working on mitochondrial translation, ribosome biogenesis stress, or p53 pathway activation in mammalian cell and tissue models.