Anti-MPO Antibody

Rabbit polyclonal antibody reagents from Antibodies.com support research into myeloperoxidase biology and neutrophil-driven inflammation. Supplied at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.3, this unconjugated preparation is packaged as a 100 µl aliquot in a single vial and validated for Western blot workflows on human and mouse samples. The antibody binds myeloperoxidase, a heme-containing peroxidase concentrated in the azurophilic granules of neutrophils that drives the microbicidal conversion of hydrogen peroxide and chloride into hypochlorous acid during the respiratory burst. Investigators probing innate immunity, cardiovascular risk biomarkers, and MPO-ANCA associated small vessel vasculitis routinely probe neutrophil lysates, differentiated HL-60 cell extracts, and inflamed tissue homogenates with polyclonal anti-MPO reagents under reducing SDS-PAGE conditions. Keep the vial refrigerated for active projects; aliquot and freeze at -20 °C for longer term storage to limit damage from repeated freeze-thaw cycles.