Anti-MOG Antibody

This rabbit polyclonal primary antibody targets Myelin Oligodendrocyte Glycoprotein (MOG), a transmembrane glycoprotein expressed on the outer surface of the myelin sheath. Researchers use MOG-directed reagents to investigate central nervous system myelination, oligodendrocyte biology, and autoimmune demyelinating disease, including Multiple Sclerosis and the recently delineated MOG antibody-associated disease (MOGAD). The unconjugated antibody format allows flexible pairing with custom secondary detection systems across diverse experimental designs.

Validated by Antibodies.com for Western blot, immunohistochemistry, and immunofluorescence, the reagent shows reactivity toward human, mouse, and rat MOG, supporting cross-species experimental work. It is supplied as a 100 µl liquid aliquot at a working titer suitable for standard immunolabeling on tissue sections, primary oligodendrocyte cultures, and demyelination injury models. Storage recommendations call for refrigerated handling and minimal freeze-thaw cycles to maintain antigen affinity across longitudinal studies, and the polyclonal nature of the reagent enables recognition of multiple epitopes within the MOG extracellular Ig-like domain.