Anti-MOCS2 Antibody

A rabbit polyclonal IgG raised against MOCS2 (Molybdenum Cofactor Synthesis 2), a bicistronic gene product that forms the small (MOCS2A) and large (MOCS2B) subunits of molybdopterin synthase. This terminal enzyme of the molybdenum cofactor (Moco) biosynthetic pathway transfers sulfur to precursor Z, generating the dithiolene moiety required by sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. From Antibodies.com, the reagent is supplied unconjugated and validated specifically for Western blot (WB) detection of endogenous mouse MOCS2 protein.

Provided as a 100 µL liquid aliquot, the antibody is suited to standard immunoblotting of mouse cell and tissue lysates. Researchers investigating molybdenum cofactor deficiency type B, a rare autosomal recessive neurometabolic disorder caused by MOCS2 loss-of-function mutations, routinely quantify residual MOCS2 expression in patient-derived fibroblasts and corresponding murine knockout models. The unconjugated format permits flexible pairing with HRP-, fluorophore-, or biotin-conjugated secondary reagents, and the polyclonal nature increases the likelihood of detecting both MOCS2 splice isoforms.

Recommended handling includes brief refrigerated storage, aliquoting on first use, and avoiding repeated freeze-thaw cycles to preserve polyclonal titer. For research use only; not intended for diagnostic or therapeutic applications.