Anti-MNDA Antibody

MNDA (Myeloid Cell Nuclear Differentiation Antigen) is an interferon-inducible nuclear factor belonging to the HIN-200 family of hematopoietic regulators, where it participates in myeloid differentiation and innate immune responses. This polyclonal rabbit reagent from Antibodies.com binds the human MNDA protein and is supplied as 100 µL of unconjugated antiserum, validated for western blot, immunohistochemistry, and ELISA workflows.

MNDA expression is largely restricted to cells of the granulocyte-monocyte lineage, including mature monocytes, macrophages, and granulocytes, which makes this antibody a useful marker in lymphoma subtyping and hematopathology research. Published pathology studies have reported MNDA positivity in classical Hodgkin lymphoma and anaplastic large cell lymphoma, where it complements other myeloid antigens during differential diagnosis. Because MNDA accumulates in the nucleus, the antibody yields distinct staining in formalin-fixed paraffin-embedded tissue sections, while the protein's induction by type I interferons ties the target to studies of cytokine signaling and antiviral defense.

Store the vial refrigerated in working aliquots; for longer-term storage, freeze at -20 °C and limit freeze-thaw cycles to preserve activity. The polyclonal format recognizes multiple epitopes across the antigen, improving sensitivity when MNDA is expressed at low abundance. Researchers investigating myelopoiesis, monocyte biology, or hematological biomarkers will find this reagent a focused tool for profiling MNDA distribution in human tissues, primary cells, and relevant disease models.