Anti-MMP9 Antibody

Matrix metalloproteinase 9, also referred to as 92 kDa gelatinase B or type IV collagenase, is a zinc-dependent endopeptidase that cleaves extracellular matrix and basement membrane components during tissue remodeling, tumor invasion, inflammatory responses, and cardiovascular pathology. Antibodies.com provides a rabbit polyclonal antibody raised against this target, validated for Western blot and immunohistochemistry on human, mouse, and rat specimens to support cross-species comparative studies.

The unconjugated reagent is supplied as a 100 µl liquid at 1 mg/ml in phosphate buffered saline containing 0.05% sodium azide at approximately pH 7.2, ready for direct dilution into standard blocking or antibody diluent buffers. The polyclonal format offers epitope diversity that improves recognition of denatured targets on Western blot membranes and partially degraded antigens in fixed tissue sections, while the unconjugated presentation lets researchers pair the antibody with their preferred detection labels and secondary systems.

Typical applications include profiling gelatinase activity in cancer invasion and metastasis models, characterizing neutrophil and macrophage responses in inflammatory disease, monitoring atherosclerotic plaque instability, and tracking remodeling during wound healing and myocardial injury studies. The vial format supports short-term storage at 4 °C for active use, with aliquoting and freezing at -20 °C recommended for long-term archiving across repeated freeze-thaw cycles.