Anti-MMP8 Antibody

MMP8 (matrix metalloproteinase 8, also known as neutrophil collagenase) is a zinc-dependent endopeptidase that cleaves type I, II, and III collagens during neutrophil-driven extracellular matrix turnover. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is raised against human MMP8 and validated for Western blot detection across both human and mouse samples, supporting studies of neutrophil degranulation, inflammatory cartilage resorption, periodontal tissue breakdown, and matrix remodeling in cardiovascular, pulmonary, or wound-healing models. Supplied as 200 µL of antiserum in a single vial, the antibody can be aliquoted to limit freeze-thaw cycles and stored refrigerated to preserve reagent activity. Researchers commonly apply it to lysates of stimulated neutrophils, macrophages, or granulocytes, to conditioned media from inflammatory cell cultures, and to tissue extracts from gingival, synovial, or atherosclerotic lesions, where it reveals the latent pro-form and processed MMP8 species by standard SDS-PAGE immunoblotting under reducing conditions.