Anti-MMP8 Antibody

This rabbit polyclonal antibody targets matrix metalloproteinase 8 (MMP8), a zinc-dependent endopeptidase also known as neutrophil collagenase or PMNL collagenase. Produced by Antibodies.com for research use only, the reagent is supplied as 100 µl of unconjugated antisera in a single vial and is validated for Western blot and immunohistochemistry workflows on human samples.

MMP8 cleaves the triple helix of fibrillar collagens I, II, and III and is implicated in neutrophil-mediated inflammation, periodontal tissue breakdown, rheumatoid arthritis progression, and tumor invasion pathways. Researchers investigating these processes can use the antibody to probe whole-cell lysates, formalin-fixed tissue sections, or conditioned media for the active and latent forms of the enzyme.

The polyclonal format increases the likelihood of recognizing multiple epitopes on the target, which is helpful when studying proteolytic cleavage fragments or variable expression across tissues. Handle the vial on ice during use and return it to refrigerated storage between experiments to preserve antibody reactivity over the working life of the reagent.