Anti-MMP7 Antibody

MMP7 (matrilysin) is a zinc-dependent matrix metalloproteinase involved in extracellular matrix turnover and tissue remodeling, with documented roles in wound healing, mucosal immunity, and tumor progression across multiple epithelial cancers. Antibodies.com supplies this rabbit polyclonal anti-MMP7 reagent as an unconjugated primary antibody in 100 µl format, validated for western blot and immunohistochemistry workflows against human, mouse, and rat samples.

The polyclonal format means the reagent recognizes multiple epitopes across the matrilysin protein, which is useful when probing processed or partially degraded forms of the enzyme that are common in tumor tissue lysates. Researchers studying colorectal, pancreatic, gastric, and non-small cell lung cancer frequently use MMP7 as a marker of epithelial-mesenchymal transition and adverse prognosis, making this antibody a practical choice for studies that combine protein-level validation by WB with localization by IHC on matched tumor and adjacent normal sections. The unconjugated presentation also leaves room for downstream fluorophore or enzyme conjugation in custom multiplex panels, including tyramide signal amplification for low-abundance targets in formalin-fixed tissue.

Storage at -20 °C in working aliquots is recommended to limit freeze-thaw cycles, with brief centrifugation before use to recover full volume from the vial. Pairing the reagent with appropriate positive controls (such as MMP7-expressing colorectal lines) and negative controls (knockdown or knockout material) gives a reliable readout in both blotting and staining setups.