Anti-MMP14 Antibody

MMP14 (also known as MT1-MMP) is a membrane-anchored matrix metalloproteinase that drives extracellular matrix turnover, cell invasion, and angiogenic signaling, making it a frequent focus in cancer metastasis, tissue remodeling, and wound-healing studies. This Antibodies.com reagent is a rabbit polyclonal antibody raised against MMP14, supplied as 100 µl of unconjugated antiserum suitable for Western blot and immunohistochemistry workflows.

Validated reactivity across human, mouse, and rat samples lets researchers probe MMP14 expression in tumor sections, cultured cell lysates, and xenograft or knockout tissue panels without switching primaries between species. Common applications include tracking MT1-MMP upregulation in invasive carcinoma models, confirming knockout efficiency in genetically modified cell lines, and mapping protease localization at the leading edge of migrating cells. The unconjugated format also allows downstream pairing with HRP, biotin, or fluorophore-conjugated secondary antibodies for chromogenic, fluorescence, or multiplexed imaging detection.